The Histidine-binding Protein J Is a Component of Histidine Transport
نویسندگان
چکیده
منابع مشابه
The histidine-binding protein J, a histidine transport component, has two different functional sites.
متن کامل
Components of histidine transport: histidine-binding proteins and hisP protein.
The high-affinity (K(m) = 3 x 10(-8) M) transport system for histidine in Salmonella typhimurium has been resolved into three components: J, K, and P. J, which is a histidine-binding protein released by osmotic shock, is specified by the hisJ gene: hisJ mutants lack the binding protein and are defective in histidine transport. Another class of mutants-dhuA, which is closely linked to hisJ-has f...
متن کاملThe hisP protein, a known histidine transport component in Salmonella typhimurium, is also an arginine transport component.
The hisP protein is an essential component of the high-affinity histidine transport system in Salmonella typhimurium. Our present studies demonstrate that this protein is also an essential component of an arginine transport system. Strains with a mutation in the hisP gene are unable to transport arginine for use as a sole nitrogen source. However, such strains have normal high-affinity transpor...
متن کاملIdentification of a membrane protein as a histidine transport component in Salmonella typhimurium.
A component of high-affinity histidine transport in Salmonella typhimurium has been identified. It is a basic (pI about 9.0) membrane-bound protein, the P protein. It is shown to be coded for by the distal half of the previously described hisP gene by analysis of numerous hisP mutants, two of which exhibit P proteins with altered electrophoretic mobilities. Upon separation of the cytoplasmic (i...
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Carboplatin is a second-generation platinum anticancer agent used for the treatment of a variety of cancers. Previous X-ray crystallographic studies of carboplatin binding to histidine (in hen egg-white lysozyme; HEWL) showed the partial conversion of carboplatin to cisplatin owing to the high NaCl concentration used in the crystallization conditions. HEWL co-crystallizations with carboplatin i...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45077-1